ABSTRACT
Background:A surge of mucormycosis during the second wave of COVID intrigued the doctors in India to look for the epidemiology of the illness.Diabetes is the most common risk factor for mucormycosis.COVID can cause hyperglycemia due to various reasons.In this study,we describe the outcome of post COVID mucormycosis with respect to the glycemic status of the patient. (1)To describe the glycemic parameters of patients with COVID-19 Associated M Objectives: ucormycosis.(2)To describe the one month outcome of the patients.(3)To compare patients with Newly Diagnosed Diabetes Mellitus Post COVID-19 and patients having preexisting diabetes mellitus. 75 patients with probable or proven mucormycosis wit Methodology: h history of COVID atleast 2 weeks before were randomly selected from the mucor ward of Rajiv Gandhi Government General Hospital and their glycemic profile assessed.They were followed up for one month and the results were statistically analyzed. Regarding the prior CO Results: VID illness,patients had a median hospital stay of 7 days,received 5 days of intravenous steroids and 3.48 days of supplemental oxygen.Patients who had hyperglycemia during COVID also had statistically significantly higher iv steroid use and higher need for oxygen.There was a statistically very significant(p<0.001) increase in the number of diabetics post COVID(from 57.3% prior to COVID to 90.7% post COVID).Majority of the Mucormycosis patients(69.3%) had severe hyperglycemia during presentation.Pre-existing diabetics had a statistically significant higher incidence of sepsis and renal failure during treatment for mucormycosis.Otherwise,there was no significant difference in outcome between various grades of severity of hyperglycemia,and no distinction was found between pre-existing diabetics and newly diagnosed diabetics
ABSTRACT
Background: An alarming increase in Gestational diabetes mellitus (GDM) cases worldwide elevates concern regarding the consequences including fetal macrosomia, preeclampsia and many more. Plasma homocysteine levels which has direct impact on to endothelial function of blood vessels. The relationship of homocysteine and GDM is yet to be clarified.Methods: This single centre prospective observational study was conducted in Department of Obstetrics and Gynaecology of Thanjavur medical college hospital among 50 pregnant primi and multi gravida patients with normal pregnancy and gestational diabetes mellitus to assess the association and comparison of serum homocysteine levels in both groups.Results: The mean value of homocysteine in control group was 3.8 ± 0.95 and in gestational diabetes patients was 16.30±6.09. On comparison, found that there was hyperhomocysteinemia among GDM patients with normal pregnancy and results were statistically significant (T= -9.024 Df=48.000 <0.05).Conclusions: In this comparative and correlative study, we found that patients with gestational diabetes mellitus have higher serum homocysteine levels in comparison with normal pregnant women. Hyperhomocysteinemia is found to be an independent risk factor for gestational diabetes mellitus patients. Further investigations are needed to follow up for these patients in the postpartum period and later in their life.